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Red vine leaf AS 195. The absence of mutagenic activity in human urine following consumption of red wine or grape juice. Edirisinghe, I., Burton-Freeman, B., and Tissa, Kappagoda C. Mechanism of the endothelium-dependent relaxation evoked by a grape seed extract. Ward NC, Hodgson JM, Croft KD, et al. Jeronimo, E., Alfaia, C. M., Alves, S. P., Dentinho, M. T., Prates, J. F., Hirschfield, S. L., and Coffey, R. Endothelium-dependent vasorelaxing activity of wine and other grape products. A rapid method for quantifying aroma precursors: Application to grape extract, musts and wines made from several varieties. Bombardelli E, Morazzoni P. Fitoterapia 1995;LXVI:291-317. Visit the FDA MedWatch website or call 1-800-FDA-1088. Am J Physiol 1993;265(2 Pt 2):H774-H778. What is red vine leaf commonly used for?
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J Med Food 2011;14(1-2):69-78. Bagchi, D., Bagchi, M., Stohs, Sj, Ray, S. D., Sen, C. K., and Preuss, H. G. Cellular protection with proanthocyanidins derived from grape seeds. Disabled or chronically sick people can claim VAT relief on purchases for personal or domestic use that are applicable to their disability or sickness. Liu, T., Zhao, J., Li, H., and Ma, L. Evaluation on anti-hepatitis viral activity of Vitis vinifer L. Molecules. Monsieur, R. and Van, Snick G. [Efficacy of the red vine leaf extract AS 195 in Chronic Venous Insufficiency]. This kind of dose responsiveness is generally taken as good evidence that a treatment is actually effective.
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Conclusions: Red vine leaf extract had a beneficial therapeutic role in patients with CVI. Boyle P, Diehm C, Robertson C. Meta-analysis of clinical trials of Cyclo 3 Fort in the treatment of chronic venous insufficiency. 2006;44(10):1758-1767. Grape contains flavonoids, which can have antioxidant effects, lower the levels of low density lipoproteins (LDLs, or "bad cholesterol"), relax blood vessels, and reduce the risk of coronary heart disease. It is important to ensure that symptoms are not an indication of a more serious medical condition, such as phlebitis or thrombosis. Take for at least 6 weeks on a regular basis for maximum benefit. Rehn D, Unkauf M, Klein P, et al. Venous insufficiency. Ther 2007;6(3):995-1005. Comparative antioxidant and cytotoxic effect of procyanidin fractions from grape and pine.
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Carcinogenesis 2009;30(4):636-644. Clinical articles with discussion handouts and online assessments. Early research suggests that whole grapes might improve some of the risk factors associated with metabolic syndrome, a cluster of conditions that increase the risk for heart disease, in men. Paroven and graduated compression hosiery for superficial venous insufficiency. Xie, Q., Bedran-Russo, A. K., and Wu, C. In vitro remineralization effects of grape seed extract on artificial root caries. 1-25-2006;95(6):187-190. Some people use red vine leaf extracts together with compression stockings, while others use them on their own, depending on the severity of their symptoms. J Chem 2-8-2006;54(3):688-693. Taking grape seed extract by mouth might help decrease stress on the eyes from glare. Similarly, a 2-month, double-blind, placebo-controlled trial of 40 individuals with chronic venous insufficiency found that 100 mg 3 times daily of OPCs from pine bark significantly reduced edema, pain, and the sensation of leg heaviness. Skarpan´ska-Stejnborn, A., Basta, P., Pilaczyn´ska-Szczesniak, L., and Horoszkiewicz-Hassan, M. Black grape extract supplementation attenuates blood oxidative stress in response to acute exercise. In terms of safety and tolerance, red vine leaf extract proved good or satisfactory, which was expected from a flavonoid-rich natural product. Res 2005;49(12):1112-1119.
All participants were also fitted with standard compression stockings and wore them for the duration of the trial. Percival, S. Grape consumption supports immunity in animals and humans. Bagchi D, Bagchi M, Stohs SJ, et al. Early research suggests grape seed extract containing chemicals called proanthocyanidins might improve night vision. 2012;3(10):995-1007. J 5-18-2007;368(5):1345-1357. Aslan, Y., Erduran, E., Mocan, H., Gedik, Y., Okten, A., Soylu, H., and Deger, O. Absorption of iron from grape-molasses and ferrous sulfate: a comparative study in normal subjects and subjects with iron deficiency anemia. Med Int 1982;16(11):432-434.
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